GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs2985684 | 1 | rs11157696 | chr14:50105746 | RPL36AL | chr14:50085407-50087349:- | -0.17 | -5.55 | 3.68E-8 | Carotid intima media thickness |
| BRCA | cis | rs11159086 | 1 | rs11159086 | chr14:74962275 | TMEM90A | chr14:74872596-74892805:- | -0.16 | -3.74 | 0.000197 | Advanced glycation end-product levels |
| BRCA | cis | rs11758351 | 1 | rs111596617 | chr6:26191678 | HIST1H3E | chr6:26224427-26226589:+ | 0.35 | 6.81 | 1.61E-11 | Renal underexcretion gout;Gout |
| BRCA | cis | rs11164654 | 1 | rs11164654 | chr1:92968312 | EVI5 | chr1:92974255-93257961:- | -0.16 | -4.38 | 1.28E-5 | Cholesterol, total;LDL cholesterol |
| BRCA | cis | rs1116547 | 1 | rs1116547 | chr5:112680337 | YTHDC2 | chr5:112849410-112930979:+ | 0.15 | 4.29 | 1.96E-5 | Cerebral amyloid angiopathy |
| BRCA | cis | rs867186 | 1 | rs11167260 | chr20:33775200 | PROCR | chr20:33758727-33765164:+ | -0.26 | -5.15 | 3.16E-7 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| BRCA | cis | rs7714584 | 1 | rs11167515 | chr5:150239471 | LOC134466 | chr5:150310000-150326146:- | 0.34 | 7.81 | 1.35E-14 | Crohn's disease |
| BRCA | cis | rs11168618 | 1 | rs11168618 | chr12:48933233 | TROAP | chr12:49716971-49725513:+ | -0.06 | -3.62 | 0.000314 | Adiponectin levels |
| BRCA | cis | rs755109 | 1 | rs111696803 | chr9:100696636 | C9orf156 | chr9:100666772-100684852:- | -0.17 | -4.62 | 4.26E-6 | Quantitative traits |
| BRCA | cis | rs2120991 | 1 | rs11170737 | chr12:54279604 | LOC400043 | chr12:54519855-54526619:+ | -0.13 | -3.46 | 0.000558 | Biliary atresia |
| BRCA | cis | rs2066819 | 1 | rs11171803 | chr12:56718422 | COQ10A | chr12:56660642-56664748:+ | -0.28 | -3.89 | 0.000105 | Psoriasis vulgaris |
| BRCA | cis | rs2066819 | 1 | rs11171803 | chr12:56718422 | RPS26 | chr12:56435686-56438005:+ | -0.3 | -3.82 | 0.00014 | Psoriasis vulgaris |
| BRCA | cis | rs2066819 | 1 | rs11171803 | chr12:56718422 | SLC39A5 | chr12:56623820-56631627:+ | -0.25 | -3.67 | 0.000255 | Psoriasis vulgaris |
| BRCA | cis | rs2066819 | 1 | rs11171806 | chr12:56733531 | COQ10A | chr12:56660642-56664748:+ | 0.29 | 4.02 | 6.24E-5 | Psoriasis vulgaris |
| BRCA | cis | rs2066819 | 1 | rs11171806 | chr12:56733531 | SLC39A5 | chr12:56623820-56631627:+ | 0.25 | 3.74 | 0.000197 | Psoriasis vulgaris |